Cannabidiol: An Antibiotic Promising
Compound
The researchers imitated a 2 week
patient care in laboratory models to assess the compound's antibiotic
abilities. They observed that Cannabidiol (CBD) is especially effective at
breaking down biofilms (slimy accumulations of bacteria) from these models,
improving their odds of survival against current antibiotic therapies. CBD can
suppress drug-resistant bacteria, comprising those causing infections such as
gonorrhoea, meningitis and legionnaire disease, as an active nonpsychotic
compound present in cannabis. Certain forms of Gram-negative bacteria have been
shown to be destroyed by CBD for the first time. This bacteria have an external
outer membrane, an additional line of protection that makes it more difficult
to penetrate antibiotics. The researchers have observed that CBD exhibited a
low propensity in bacteria to induce drug resistance. This held so even though,
during the therapy process, they accelerated future drug tolerance by
increasing CBD levels. Although researchers believe that by bursting their
outer cell membranes, CBD destroys bacteria, they state that further analysis
is needed to validate the mechanism of action. In the meanwhile, they have
discovered that synthetically generated chemical CBD analogues function in the
killing of bacteria with equal efficacy. A per researchers, this is
particularly exciting because there have been no new molecular classes of
antibiotics for Gram-negative infections discovered and approved since the
1960s, and we can now consider designing new analogues of CBD within improved properties."
Researchers are now preparing to perform more experiments on the mode of action
of cannabis as an antibiotic, means of enhancing its potency, and related
effects of molecules. In the meantime, for a topical CBD formulation capable of
decolonizing MRSA before treatment, they are waiting for Phase 2A trials to
commence earlier this year. They
hope this will pave the way for more trials for diseases such as meningitis, gonorrhoea,
and plague of legionnaires.
Great news
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